Trade Mark:
Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet
DRUG CLASS AND MECHANISM
Metformin is an oral medication that lowers blood glucose (sugar) and is used for treating type 2 diabetes. Insulin is a hormone produced by the pancreas that controls glucose levels in blood by reducing the amount of glucose made by the liver and by increasing the removal of glucose from the blood by muscle and fat tissues. As a result, blood glucose levels fall. Diabetes caused by a decrease in production of insulin that causes increased production of glucose by the liver, and reduced uptake (and effects) of insulin on fat and muscle tissues. Metformin acts by increasing the sensitivity of liver, muscle, fat, and other tissues to the uptake and effects of insulin. These actions lower the level of sugar in the blood.
Unlike glucose–lowering drugs of the sulfonylurea class, for example gliburid (Micronase; DiaBeta) or glipizid (Glucotrol), metformin does not increase the concentration of insulin in the blood and, therefore, does not cause excessively low blood glucose levels (hypoglycemia) when used alone. In scientific studies, metformin reduced the complications of diabetes such as heart disease, blindness and kidney disease. Metformin was approved by the FDA in December 1994
Most of people around the world about several years next will have diabetes disease. The quantity is very significat,And according to study that diabetes people will die about 15 years early than normal people cause complicated disease like heart disease, stroke, kidney failure and many others complication disease
Thursday, January 24, 2008
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